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Clinical Perspectives on the Diagnostic Assessment of Individuals with FASD

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Abstract

Fetal Alcohol Spectrum Disorder (FASD) is a globally prevalent disorder resulting from prenatal exposure to alcohol. Early diagnosis is key to appropriate and targeted early interventions. Early identification is facilitated by clinician education, multidisciplinary communication, and community partnerships to provide appropriate support and resources for families and clinical teams involved in their care. The purpose of this chapter is to provide clinicians with an overview of the diagnostic assessment of individuals with prenatal alcohol exposure.

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References

  1. Lange S, Probst C, Gmel G, Rehm J, Burd L, Popova S. Global prevalence of fetal alcohol Spectrum disorder among children and youth: a systematic review and meta-analysis. JAMA Pediatr. 2017a;171(10):948–56.

    Article  Google Scholar 

  2. May PA, Chambers CD, Kalberg WO, Zellner J, Feldman H, Buckley D, Kopald D, Hasken JM, Xu R, Honerkamp-Smith G, Taras H, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Vaux K, Jewett T, Elliott AJ, Kable JA, Akshoomoff N, Falk D, Arroyo JA, Hereld D, Riley EP, Charness ME, Coles CD, Warren KR, Jones KL, Hoyme HE. Prevalence of fetal alcohol Spectrum disorders in 4 US communities. JAMA. 2018;319(5):474–82.

    Article  Google Scholar 

  3. Popova S, Lange S, Probst C, Parunashvili N, Rehm J. Prevalence of alcohol consumption during pregnancy and fetal alcohol Spectrum disorders among the general and aboriginal populations in Canada and the United States. Eur J Med Genet. 2017;60(1):32–48.

    Article  Google Scholar 

  4. Schmidt KA, Lancia AJ, Alvi S, Aldag JC. Alcohol reduction in the first trimester is unrelated to smoking, patient or pregnancy characteristics. Addict Behav Rep. 2017;5:43–8.

    Google Scholar 

  5. Streissguth AP, Barr HM, Sampson PD, Bookstein FL, Darby BL. Neurobehavioral effects of prenatal alcohol: part I. research strategy. Neurotoxicol Teratol. 1989;11(5):461–76.

    Article  CAS  Google Scholar 

  6. Cook JL, Green CR, Lilley CM, Anderson SM, Baldwin ME, Chudley AE, Conry JL, LeBlanc N, Loock CA, Lutke J, Mallon BF, McFarlane AA, Temple VK, Rosales T, Canada Fetal Alcohol Spectrum Disorder Research, N. Fetal alcohol spectrum disorder: a guideline for diagnosis across the lifespan. CMAJ. 2016;188(3):191–7.

    Article  Google Scholar 

  7. Leibson T, Neuman G, Chudley AE, Koren G. The differential diagnosis of fetal alcohol spectrum disorder. J Popul Ther Clin Pharmacol. 2014;21(1):e1–e30.

    Google Scholar 

  8. Lussier AA, Weinberg J, Kobor MS. Epigenetics studies of fetal alcohol spectrum disorder: where are we now? Epigenomics. 2017;9(3):291–311.

    Article  CAS  Google Scholar 

  9. Hoyme HE, Kalberg WO, Elliott AJ, Blankenship J, Buckley D, Marais AS, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Jewett T, Coles CD, Chambers C, Jones KL, Adnams CM, Shah PE, Riley EP, Charness ME, Warren KR, May PA. Updated clinical guidelines for diagnosing fetal alcohol Spectrum disorders. Pediatrics. 2016;138(2)

    Google Scholar 

  10. Watkins RE, Elliott EJ, Wilkins A, Mutch RC, Fitzpatrick JP, Payne JM, Jones HM, Latimer J, Hayes L, Halliday J, Miers S, Russell E, Burns L, McKenzie A, Peadon E, Carter M, Bower C. Recommendations from a consensus development workshop on the diagnosis of fetal alcohol spectrum disorders in Australia. BMC Pediatr. 2013;13(1):156.

    Article  Google Scholar 

  11. Petrelli B, Weinberg J, Hicks GG. Effects of prenatal alcohol exposure (PAE): insights into FASD using mouse models of PAE. Biochem Cell Biol. 2018;96(2):131–47.

    Article  CAS  Google Scholar 

  12. Lussier AA, Morin AM, MacIsaac JL, Salmon J, Weinberg J, Reynolds JN, Pavlidis P, Chudley AE, Kobor MS. DNA methylation as a predictor of fetal alcohol spectrum disorder. Clin Epigenetics. 2018;10:5.

    Article  Google Scholar 

  13. Popova S, Lange S, Shield K, Mihic A, Chudley AE, Mukherjee RAS, Bekmuradov D, Rehm J. Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis. Lancet. 2016;387(10022):978–87.

    Article  Google Scholar 

  14. Astley S. Diagnostic guide for fetal alcohol Spectrum disorders: the 4-digit diagnostic code. 3rd ed. Seattle: University of Washington; 2004.

    Google Scholar 

  15. Cranston ME, Mhanni AA, Marles SL, Chudley AE. Concordance of three methods for palpebral fissure length measurement in the assessment of fetal alcohol spectrum disorder. Can J Clin Pharmacol. 2009;16(1):e234–41.

    Google Scholar 

  16. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.

    Book  Google Scholar 

  17. Astley SJ, Stachowiak J, Clarren SK, Clausen C. Application of the fetal alcohol syndrome facial photographic screening tool in a foster care population. J Pediatr. 2002;141(5):712–7.

    Article  Google Scholar 

  18. Popova S, Lange S, Burd L, Rehm J. Canadian children and youth in care: the cost of fetal alcohol Spectrum disorder. Child Youth Care Forum. 2014;43:83–96.

    Article  Google Scholar 

  19. Colby JM, Adams BC, Morad A, Presley LD, Patrick SW. Umbilical cord tissue and meconium May not be equivalent for confirming in utero substance exposure. J Pediatr; 2018.

    Google Scholar 

  20. Wabuyele SL, Colby JM, McMillin GA. Detection of drug-exposed newborns. Ther Drug Monit. 2018;40(2):166–85.

    Article  CAS  Google Scholar 

  21. Carter RC, Jacobson JL, Molteno CD, Dodge NC, Meintjes EM, Jacobson SW. Fetal alcohol growth restriction and cognitive impairment. Pediatrics. 2016;138(2)

    Google Scholar 

  22. Watkins RE, Elliott EJ, Mutch RC, Payne JM, Jones HM, Latimer J, Russell E, Fitzpatrick JP, Hayes L, Burns L, Halliday J, D'Antoine HA, Wilkins A, Peadon E, Miers S, Carter M, O'Leary CM, McKenzie A, Bower C. Consensus diagnostic criteria for fetal alcohol spectrum disorders in Australia: a modified Delphi study. BMJ Open. 2012;2(5)

    Google Scholar 

  23. Caputo C, Wood E, Jabbour L. Impact of fetal alcohol exposure on body systems: a systematic review. Birth Defects Res C Embryo Today. 2016;108(2):174–80.

    Article  CAS  Google Scholar 

  24. Hanlon-Dearman A, Green CR, Andrew G, LeBlanc N, Cook JL. Anticipatory guidance for children and adolescents with fetal alcohol Spectrum disorder (FASD): practice points for primary health care providers. J Popul Ther Clin Pharmacol. 2015;22(1):e27–56.

    Google Scholar 

  25. Abele-Webster LA, Magill-Evans JE, Pei JR. Sensory processing and ADHD in children with fetal alcohol spectrum disorder. Can J Occup Ther. 2012;79(1):60–3.

    Article  Google Scholar 

  26. Jirikowic T, Olson HC, Kartin D. Sensory processing, school performance, and adaptive behavior of young school-age children with fetal alcohol spectrum disorders. Phys Occup Ther Pediatr. 2008b;28(2):117–36.

    Article  Google Scholar 

  27. Chen ML, Olson HC, Picciano JF, Starr JR, Owens J. Sleep problems in children with fetal alcohol spectrum disorders. J Clin Sleep Med. 2012;8(4):421–9.

    Article  Google Scholar 

  28. Hanlon-Dearman A, Chen ML, Olson HC. Understanding and managing sleep disruption in children with fetal alcohol spectrum disorder. Biochem Cell Biol. 2018;96(2):267–74.

    Article  CAS  Google Scholar 

  29. Jirikowic T, Kartin D, Olson HC. Children with fetal alcohol spectrum disorders: a descriptive profile of adaptive function. Can J Occup Ther. 2008a;75(4):238–48.

    Article  Google Scholar 

  30. Goril S, Zalai D, Scott L, Shapiro CM. Sleep and melatonin secretion abnormalities in children and adolescents with fetal alcohol spectrum disorders. Sleep Med. 2016;23:59–64.

    Article  Google Scholar 

  31. Ichikawa K, Fujiwara T, Kawachi I. Prenatal alcohol exposure and child psychosocial behavior: a sibling fixed-effects analysis. Front Psych. 2018;9:570.

    Article  Google Scholar 

  32. Khoury JE, Jamieson B, Milligan K. Risk for childhood internalizing and externalizing behavior problems in the context of prenatal alcohol exposure: a meta-analysis and comprehensive examination of moderators. Alcohol Clin Exp Res. 2018;

    Google Scholar 

  33. Terband H, Spruit M, Maassen B. Speech impairment in boys with fetal alcohol Spectrum disorders. Am J Speech Lang Pathol. 2018;27(4):1405–25.

    Article  Google Scholar 

  34. Wyper KR, Rasmussen CR. Language impairments in children with fetal alcohol spectrum disorders. J Popul Ther Clin Pharmacol. 2011;18(2):e364–76.

    Google Scholar 

  35. Kully-Martens K, Denys K, Treit S, Tamana S, Rasmussen C. A review of social skills deficits in individuals with fetal alcohol spectrum disorders and prenatal alcohol exposure: profiles, mechanisms, and interventions. Alcohol Clin Exp Res. 2012;36(4):568–76.

    Article  Google Scholar 

  36. Stevens SA, Major D, Rovet J, Koren G, Fantus E, Nulman I, Desrocher M. Social problem solving in children with fetal alcohol spectrum disorders. J Popul Ther Clin Pharmacol. 2012;19(1):e99–110.

    Google Scholar 

  37. Coles CD, Kable JA, Taddeo E, Strickland D. GoFAR: improving attention, behavior and adaptive functioning in children with fetal alcohol spectrum disorders: brief report. Dev Neurorehabil. 2018;21(5):345–9.

    Article  Google Scholar 

  38. Kully-Martens K, Pei J, Kable J, Coles CD, Andrew G, Rasmussen C. Mathematics intervention for children with fetal alcohol spectrum disorder: a replication and extension of the math interactive learning experience (MILE) program. Res Dev Disabil. 2018;78:55–65.

    Article  Google Scholar 

  39. Paley B, O'Connor MJ. Intervention for individuals with fetal alcohol spectrum disorders: treatment approaches and case management. Dev Disabil Res Rev. 2009;15(3):258–67.

    Article  Google Scholar 

  40. de Beer M, Kritzinger A, Zsilavecz U. Young children with fetal alcohol spectrum disorder–communication profiles. S Afr J Commun Disord. 2010;57:33–42.

    Google Scholar 

  41. Franklin L, Deitz J, Jirikowic T, Astley S. Children with fetal alcohol spectrum disorders: problem behaviors and sensory processing. Am J Occup Ther. 2008;62(3):265–73.

    Article  Google Scholar 

  42. Lange S, Rovet J, Rehm J, Popova S. Neurodevelopmental profile of fetal alcohol Spectrum disorder: a systematic review. BMC Psychol. 2017b;5(1):22.

    Article  Google Scholar 

  43. McLachlan K, Andrew G, Pei J, Rasmussen C. Assessing FASD in young children: exploring clinical complexities and diagnostic challenges. J Popul Ther Clin Pharmacol. 2015;22(1):e108–24.

    Google Scholar 

  44. Wilhoit LF, Scott DA, Simecka BA. Fetal alcohol Spectrum disorders: characteristics, complications, and treatment. Community Ment Health J. 2017;53(6):711–8.

    Article  Google Scholar 

  45. Doyle LR, Moore EM, Coles CD, Kable JA, Sowell ER, Wozniak JR, Jones KL, Riley EP, Mattson SN, Cifasd. Executive functioning correlates with communication ability in youth with histories of heavy prenatal alcohol exposure. J Int Neuropsychol Soc. 2018;24(10):1026–37.

    Article  Google Scholar 

  46. Agnihotri S, Subramaniapillai S, Keightley M, Rasmussen C, Cameron D, Ryan J, Rovet J. Everyday memory difficulties in children and adolescents with fetal alcohol Spectrum disorder. Dev Neurorehabil. 2018:1–8.

    Google Scholar 

  47. Taylor NM, Enns LN. Age-related differences in neuropsychological assessment of fetal alcohol spectrum disorder: a cross-sectional study. Biochem Cell Biol. 2018;96(2):252–9.

    Article  CAS  Google Scholar 

  48. Weyrauch D, Schwartz M, Hart B, Klug MG, Burd L. Comorbid mental disorders in fetal alcohol Spectrum disorders: a systematic review. J Dev Behav Pediatr. 2017;38(4):283–91.

    Article  Google Scholar 

  49. Hellemans KG, Sliwowska JH, Verma P, Weinberg J. Prenatal alcohol exposure: fetal programming and later life vulnerability to stress, depression and anxiety disorders. Neurosci Biobehav Rev. 2010;34(6):791–807.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Pediatrics and Child Health, Section Head Developmental Pediatrics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada

    Ana C. Hanlon-Dearman

  2. Medical Director Manitoba FASD Centre and Provincial Network, Specialized Services for Children and Youth (SSCY), Winnipeg, MB, Canada

    Ana C. Hanlon-Dearman

  3. University of Manitoba, Past Medical Director MB FASD Centre and Network, Winnipeg, Canada

    Sally Longstaffe

  4. Max Rady College of Medicine, Acting Medical Director, Children’s Hospital Child Protection Centre, Winnipeg, Canada

    Sally Longstaffe

Authors
  1. Ana C. Hanlon-Dearman
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  2. Sally Longstaffe
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Corresponding author

Correspondence to Ana C. Hanlon-Dearman .

Editor information

Editors and Affiliations

  1. Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia

    David D. Eisenstat

  2. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

    Dan Goldowitz

  3. Department of Pediatrics and School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada

    Tim F. Oberlander

  4. Department of Pediatrics, University of Alberta, Edmonton, AB, Canada

    Jerome Y. Yager

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Hanlon-Dearman, A.C., Longstaffe, S. (2023). Clinical Perspectives on the Diagnostic Assessment of Individuals with FASD. In: Eisenstat, D.D., Goldowitz, D., Oberlander, T.F., Yager, J.Y. (eds) Neurodevelopmental Pediatrics. Springer, Cham. https://doi.org/10.1007/978-3-031-20792-1_22

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  • DOI: https://doi.org/10.1007/978-3-031-20792-1_22

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-20791-4

  • Online ISBN: 978-3-031-20792-1

  • eBook Packages: MedicineMedicine (R0)

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